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The peptide is a tripeptide composed of three amino acids it is cleaved by gastric acid and intestinal peptidases into individual amino acids before absorption, eliminating the intact copper-peptide complex required for biological activity

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Davies M, Pratley R, Hammer M, Thomsen AB, Cuddihy R

Capsaicin induces a slow inward current which is not mediated by substance P in substantia gelatinosa neurons of the rat spinal cord

However, studies were conducted in Asian populations with significantly darker baseline skin tones (Fitzpatrick IVVI), effects were not permanent, and outcomes were variable one included trial found no significant change