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Individuals may experience symptoms such as fatigue (often manifesting as that all too familiar tired but wired feeling), poor quality sleep , as well as a poor ability to handle stress
In parallel, the higher but transient P53 expression in Gstp1/2 / mice could contribute to the maintenance of the redox homeostasis and cell survival as well as the early increase in GSTM1 protein levels that blocks the TRAF2/ASK1 signaling pathway
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The GCLM gene is located on chromosome 1p22.1 and is composed of 9 exons that generate two alternatively spliced mRNAs that encode proteins of 274 amino acids (isoform 1) and 252 amino acids (isoform 2)
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