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Newer Medications For patients who cannot tolerate sequestrants or do not respond to them, newer therapies are emerging: Farnesoid X Receptor (FXR) Agonists (e.g., Obeticholic Acid): These drugs target the faulty FGF19 feedback loop seen in Type 2 BAM
Glossary of Terms Agonist A compound that binds to a receptor and activates it, producing a biological response
(With off-label use, a drug is prescribed for a condition it hasnt been approved to treat.) The two medications also have different indications
doi: 10.2337/db09-1899
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