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Inhibitors of SLC7A11 suppress cystine uptake, leading to a depletion of GSH and resulting in cell death mechanisms such as apoptosis and ferroptosis [200, 201]
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Statistical significance was estimated using Students t -test or the analysis of variance followed by Bonferronis t -test as described in the legends
Notably, in mice, these bihormonal insulin + glucagon + cells were concentrated on the periphery, where cells tend to reside
Additionally, altered pharmacokinetics could theoretically affect the medication's duration of action, though the clinical significance of this is uncertain given tirzepatide's long half-life
Patients faced months-long waits, and compounding pharmacies stepped in to fill the gap
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