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In clinical trials on insulin resistance and type 2 diabetes, phenylbutyrate could significantly improve peripheral insulin sensitivity (Rd:13.2 1.8 vs
Therapeutic strategies targeting lipid rafts (e.g., statins, sphingomyelinase inhibitors) stabilize rafts and protect the blood-brain barrier, while SOCE inhibitors and TRP channel antagonists show potential in alleviating microglial inflammation
Functional heterogeneity: The SSP exerts opposing functions in tumor cells versus tumor-associated cells, such as M2-type macrophages and CD8 + T cells
It also helps turn food into energy
p53-pS15 combined with FOXO4 in the nucleus of senescent cells inhibits p53 into the cytoplasm to mediate apoptosis and halt the cell cycle 9,11
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