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A major mechanism involves the reduction of intracellular drug accumulation through downregulation of solute carrier (SLC) transporters or upregulation of ATP-binding cassette (ABC) transporters, resulting in decreased drug efficacy

And 5-amino-1mq is the compound that researchers have developed specifically to shut it down

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Research on the regulation of the brain-gut axis with the NO pathway (Sikiric et al

In summary, ferroptosis, as a novel form of cell death, is involved in the pathogenesis of various diseases