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These features include: Asymmetry (when a line is drawn down the middle of the mole, the two sides are not the same) Irregular, rather than smooth, round borders Variation in color within the mole, with more than one color Larger than a pencil eraser Patients with numerous (over 50, for instance) benign nevi and/or multiple atypical nevi are at increased risk of melanoma and should be followed by a dermatologist

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Specifically, Lys47, Lys91, Phe112, and His114 of HGF interact with Asn393 and Phe398 of c-MET, through van der Waals and hydrogen bonding interactions (Fig

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