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In the first NEJM study, there was a higher risk of pancreatic inflammation in the semaglutide group (2% v 1.2% placebo for gallstones) however all recovered
The supplements independent effectiveness without lifestyle changes is unclear
What the Latest Research Says About Long-Term Safety The SELECT trial (published 2023) followed over 17,000 adults using semaglutide for cardiovascular outcomes over 2.4 years and found a 20% reduction in major adverse cardiac events, suggesting the medication may protect heart health independent of weight loss alone
Food thoughts get less loud
Only small amounts reach your bloodstream intact, limiting practical benefit for most people
Wegovy) are approved for use for up to 2 years under NICE guidance, usually alongside a structured weight loss programme
