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And then modal DFCs were introduced with Zendikar Rising

And the response to this has been spectacular

All of this is to say that Oko is extremely hard to answer in combat, so it largely requires a spell to deal with it (or, as we see in Throne of Eldraine Standard, you can go way over the top of its threat generation by, for example, making lots of 2/2s with Field of the Dead)

With Acid Trap Hole, you can target one of your opponents set monsters and destroy it, but only if its defense is 2000 or less

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You can only use this effect of "Reprodocus" once per turn