Thankfully, your sideboard is likely to already have answers to these kinds of opponents
This could have included art styles seen in the recent Secret Lair October Superdrop that features cards based on old horror movie posters and pulp novel covers, or even alternate that fit a bit better with the black and white style
Burn and Life Drain Burn decks deal direct damage, while Life Drain decks make opponents lose life while you gain it
In a set where more artifact creatures are being printed, there is an increased chance for a big hit
Meddling Mage There were a lot of head-scratchers or absurdly overpowered submissions at the Invitational that Chris Pikula won, but Chris instead submitted a supremely elegant design
Summary The most valuable cards in the Murder at Karlov Manor set are the special variant dossier showcase cards, some of which have invisible ink messages